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The major active effect of naltrexone is on opioid drugs, which is one class of drugs used primarily to treat pain but is also found in some prescription cough medicines. Naltrexone will block the effect of normal doses of this type of drug. There are many non-narcotic pain relievers that can be used effectively while you are on naltrexone. Otherwise, naltrexone is likely to have little impact on other medications patients commonly use such as antibiotics, non-opioid analgesics (e.g., aspirin, acetaminophen, ibuprofen), and allergy medications. You should inform our study physician (Dr. Lustig) of whatever medication you are currently taking so that possible interactions can be evaluated. Because naltrexone is broken down by the liver, other medications that can affect liver function may affect the dose of naltrexone.

It is obviously crucial to your own health that you do not use recreational drugs or opioidergic painkillers on the days you are taking the naltrexone pill.

Opioidergic drugs that you must avoid during this study include but are not limited to vicodin, Demerol, meperidine, percodan, percocet, roxicodone, oxycontin, oxyfast, codeine, morphine, fentanyl, oxycodone, hydrocodone, heroin, and methadone. If you are in any doubt about a particular drug ask one of the study staff or your personal physician.